Molecular determinants of UDP glucuronosyltransferase 1A3 and 1A4 expression [ 2007 - 2009 ]

Research Grant

Researchers: E/Pr Peter Mackenzie (Principal investigator)

Brief description Enzymes in the liver and gastrointestinal tract have a crucial role in protecting against the toxic effects of fat-soluble chemicals. Two of these enzymes called UGT1A3 and UGT1A4 have a special role in protecting against drugs and toxins that contain nitrogen groups. The levels of these two enzymes in the liver and gut vary extensively between individuals. In this project we will determine how the levels of these enzymes are controlled and what is the cause of this variability between individuals. This will help us predict those individuals who are more at risk from the adverse effects of nitrogen-containing drugs and from the toxic effects of chemicals in the diet or the environment. This project will also help us develop methods to increase the levels of these protective enzymes and help reduce the effects of exposure to toxic chemicals.

Funding Amount $AUD 516,078.39

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant