grant

Molecular characterisation of TRAIL-regulated signal transduction pathways and their role in the development, persistence, and exacerbation of allergic airways disease [ 2011 - 2014 ]

Also known as: Novel therapies for asthma

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1011153]

Researchers: Prof Joerg Mattes (Principal investigator) ,  Dr Nicole Verrills

Brief description Molecules that promote the development, persistence, and exacerbation of asthma are only poorly defined. We have discovered a novel signalling pathway that is activated in the airway wall during asthma. Blocking a molecule that activates this pathway ameliorated asthma in mice. We now want to identify all the important components of this pathway and therapeutically modulate them to prevent the development, persistence, and exacerbation of asthma.

Funding Amount $AUD 637,035.47

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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