Molecular characterisation of telomere trimming and its role in cell proliferative capacity [ 2013 - 2015 ]

Research Grant

Researchers: Prof Roger Reddel (Principal investigator) ,  A/Pr Hilda Pickett

Brief description Telomeres are protective structures at the ends of chromosomes. Telomere length is a major determinant of how many times a cell can proliferate. We have recently discovered a rapid telomere shortening process that we have called telomere trimming. We will analyse the molecular details of this process to determine whether it could be used to shorten telomeres and stop cancer cell proliferation, and whether blocking it could increase cell proliferation in patients with short telomere syndromes.

Funding Amount $AUD 403,439.75

Funding Scheme Project Grants

Notes Standard Project Grant