grant

Molecular characterisation of the dendritic cell receptor Clec9a and its ligand interactions [ 2012 - 2014 ]

Also known as: Understanding how a protein on the surface of immune cells recognises and responds to damaged and dangerous dead cells, and using an approach based on this protein to generate better vaccines.

Funded by National Health and Medical Research Council
Managed by Macfarlane Burnet Institute for Medical Research and Public Health
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1025201]

Researchers: A/Pr Mireille Lahoud (Principal investigator) ,  A/Pr Peter Czabotar ,  Prof Ken Shortman

Brief description The immune system senses danger from infectious diseases, damaged and dead cells. We identified a danger receptor, Clec9A, on a specialised cell type of the immune system in mice and humans. Clec9A recognizes and induces immunity to dangerous dead cells. Delivering vaccines to Clec9A improves vaccine responses. We will investigate how Clec9A recognises and reacts to danger, and how we can mimic this recognition to improve vaccine design.

Funding Amount $AUD 651,784.04

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Immunology | Immunology Not Elsewhere Classified | Medical and Health Sciences | cancer immunotherapy | cell death | cell surface receptor | dendritic cell | immune modulation | ligand binding | protein structure |
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