grant

Molecular and cellular characterisation of schizophrenia associated dysfunction in microRNA biogenesis [ 2010 - 2013 ]

Also known as: Gene silencing in schizophrenia

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/631057]

Researchers: Prof Murray Cairns (Principal investigator) ,  A/Pr Paul Tooney E/Pr John Rostas Prof Alan Brichta Prof Rodney Scott

Brief description We have identified substantial changes in the biogenesis of microRNA in schizophrenia. These small non-coding molecules derived from junk DNA, play a significant role in genetic regulation, with each one capable of silencing hundreds of target genes. This has major implications for schizophrenia, which is known to involve substantial changes in gene activity. The project will identify the molecular basis of this alteration in gene silencing, and its biological implications for schizophrenia.

Funding Amount $AUD 496,205.19

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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