Molecular Basis for the Mitochondrial Stress Response [ 2003-01-01 - 2006-01-31 ]

Research Grant

Researchers: Michael Ryan (Chief Investigator) ,  Prof Nicholas Hoogenraad (Chief Investigator)

Brief description Molecular Basis for the Mitochondrial Stress Response. The biogenesis of mitochondria depends on the co-ordinated expression of mitochondrial and nuclear genomes. Little is known about the extent and how the expression of both cellular genomes is co-ordinated. We have discovered a novel biological process, the mitochondrial stress response, whereby the establishment of stress within the mitochondria results in the upregulation of a suite of genes in the nucleus encoding proteins which rescue mitochondria from damage caused by stress. This project is to determine how stress is sensed in the mitochondrion and communicated to the nucleus resulting in alterations in gene expression. The project also aims to define the physiological role of mitochondrial chaperones in protein folding in the organelle.

Funding Amount $330,000

Funding Scheme Discovery Projects

View this grant in the ARC Data Portal