The molecular basis by which the interleukin-6 cytokine promotes emphysema [ 2015 - 2017 ]

Research Grant

Researchers: Prof Brendan Jenkins (Principal investigator) ,  Prof Gary Anderson ,  Prof Stefan Rose-John

Brief description Interleukin 6 (IL-6) is a potent immuno-modulatory cytokine that is commonly elevated in emphysema, the 5th leading cause of death in Australia. To understand the role of IL-6 in emphysema, we aim to demonstrate here by using a unique mouse model for IL-6-driven emphysema and clinical biopsies from emphysema patients, that IL-6 uses an alternative signalling mechanism in emphysema termed trans-signalling. Therefore this project could provide novel therapeutic targets for emphysema.

Funding Amount $AUD 659,457.15

Funding Scheme Project Grants

Notes Standard Project Grant