grant

The molecular basis of HLA-linked drug hypersensivity reactions [ 2014 - 2016 ]

Also known as: what causes drug hypersensivity?

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1063829]

Researchers: Prof Anthony Purcell (Principal investigator) ,  Dr Julian Vivian

Brief description Adverse drug reactions are one of the leading causes of death in hospitalised patients. We have discovered a new mechanism that links these reactions to recognition of drug induced changes in immunological self, resulting from interactions of drugs with immune receptors. This project probes the generality of this mechanism by examining the basis of life threatening reactions to drugs used to treat epilepsy (carbamazepine), gout (allopurinol), HIV (Nevirapine) and towards aspirin a commonly used pharmaceutical.

Funding Amount $AUD 683,040.36

Funding Scheme Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857