Molecular basis for the efficient processing of antigens taken up by Clec9A, a DAMP receptor on dendritic cells [ 2015 - 2019 ]

Research Grant

Researchers: A/Pr Mireille Lahoud (Principal investigator) ,  A/Pr Irina Caminschi ,  Prof Ken Shortman

Brief description Dendritic cells (DC) of the immune system utilise specific receptors to sense danger signals from their environment. We identified a DC danger receptor, Clec9A, which recognizes and induces immunity to “dangerous” dead cells eg. infected cells or killed tumour cells. We will investigate how DC use Clec9A to process “dangerous” dead cells, and the factors that control the potency of this immune response. This will enable us to develop novel immunotherapies for infectious diseases and cancer.

Funding Amount $AUD 1,302,392.41

Funding Scheme Project Grants

Notes Standard Project Grant