Modelling TRPV4 skeletal disorders using human iPSCs [ 2018 - 2021 ]

Research Grant

Researchers: A/Pr Shireen Lamande (Principal investigator) ,  Prof Andrew Elefanty ,  Prof Boris Martinac ,  Prof John Bateman ,  Prof Peter Mcintyre

Brief description Inherited skeletal disorders are a significant disease burden. Many gene mutations have been defined but we only have limited understanding about how they cause the disease. We will use patient skin cells and new in vitro re-programing technology to induce them to form cartilage cells to produce “disease in a dish” models of human skeletal disorders. These models will allow us to answer questions about how specific mutations cause disease and identify potential therapies

Funding Amount $AUD 1,187,583.13

Funding Scheme Project Grants

Notes Standard Project Grant