Modelling the loss of NF1 heterozygosity in congenital pseudarthrosis of the tibia (CPT). [ 2008 - 2010 ]

Research Grant

Researchers: Prof David Little (Principal investigator) ,  A/Pr Aaron Schindeler ,  A/Pr Paul Baldock ,  Prof Ian Alexander

Brief description Congenital pseudarthrosis of the tibia or CPT is a dibilitating orthopaedic condition that affects children. Healing of a CPT is poor and, even with modern surgical techniques, amputation is a frequent outcome. As a group experienced in animal models of bone healing, we are well positioned to develop advanced genetic models of CPT in mice. With a better understanding of the underlying processes in CPT we will be able to develop treatments for this severe childhood condition.

Funding Amount $AUD 482,978.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant