Modeling human Actin Related Protein 2/3 Complex subunit 1B (ARPC1B) deficiency in mice [ 2018 - 2020 ]

Research Grant

Researchers: Dr Anselm Enders (Principal investigator) ,  Dr Ian Parish ,  Dr Jane Oliaro ,  Dr Katrina Randall ,  Prof David Tscharke

Brief description The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.

Funding Amount $AUD 765,575.07

Funding Scheme Project Grants

Notes Standard Project Grant