Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/502622]Researchers: Prof Erik Thompson (Principal investigator) , Dr Mark Waltham
Brief description MMP13 is upregulated in cancer cells and in the tissue that forms around the cancer (stroma). A new MMP13-specific inhibitor reduces breast cancer growth in a mouse model, both at the primary site and also in bone. We will determine the role of MMP13 made by the cancer cells and stroma, respectively, extend the inhibitor work, and identify proteins being cleaved by MMP13. Being a late-stage manifestation, bone metastasis may represent an important clinical trial setting for MMP inhibitors.
Funding Amount $AUD 537,579.21
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 502622
- PURL : https://purl.org/au-research/grants/nhmrc/502622
