Mitogenic and metabolic signalling via the insulin recptor isoform-A [ 2010 - 2013 ]

Research Grant

Researchers: A/Pr Briony Forbes (Principal investigator) ,  A/Pr Lisandra Martin ,  Prof John Wallace ,  Prof Peter Hoffmann

Brief description A novel mechanism of stimulating cancer cell survival and growth has been identified which involves insulin and insulin-like growth factor-II acting via the insulin receptor isoform A. This proposal will identify the mechanisms by which these ligands stimulate growth rather than metabolism via the insulin receptor-A. This information will be used in future design of novel molecules to inhibit cancer growth without interfering with insulin's normal metabolic functions.

Funding Amount $AUD 533,541.03

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant