Microparticles in NASH: origins, pathogenic roles, and biomarker of disease activity [ 2013 - 2015 ]

Research Grant

Researchers: Prof Geoffrey Farrell (Principal investigator) ,  Prof Narcissus Teoh ,  The Australian National University (Managed by)

Brief description 30% of Australians have non-alcoholic fatty liver disease (NAFLD). Cirrhosis is the third cause of death; only 10-25% of NAFLD livers show steatohepatitis (NASH), which leads to cirrhosis. We have found that microparticles (MPs), small fragments of cell membranes, circulate in NASH but not in ordinary fatty liver. We will now explore ways in which MPs incite inflammation and liver fibrosis in NASH, and design new tests based on MPs to improve clinical assessment of patients with NAFLD/NASH.

Funding Amount $AUD 540,633.11

Funding Scheme Project Grants

Notes Standard Project Grant