Microevolution of Cryptococcus neoformans [ 2017 - 2020 ]

Research Grant

Researchers: A/Pr James Fraser (Principal investigator) ,  A/Pr Benjamin Schulz

Brief description The pathogen Cryptococcus neoformans is responsible for hundreds of thousands of deaths annually. If the infection is survived, relapse caused by evolved forms of the original infecting strain is common. Our research has uncovered similar genetic changes in isolates from unrelated patients that implicate epigenetic processes in relapse and reveal potential vulnerabilities of the pathogen. The proposed work is to investigate these changes to assist in our antifungal drug development efforts.

Funding Amount $AUD 793,785.09

Funding Scheme Project Grants

Notes Standard Project Grant