micro RNAs - critical regulators of Treg genes [ 2012 - 2016 ]

Research Grant

Researchers: Prof Simon Barry (Principal investigator) ,  Prof Joachim Schultze

Brief description Natural Treg are dependent on the transcription factor FOXP3, but the mechanism of action of FOXP3 is only now becoming defined for human Treg. Tregs are critical for a balanced, responsive immune system, and deviation from this balance results in autoimmune diseases or persistence of cancers. In order to intervene to treat these disease it is essential to first know what makes a normal Treg function, and to then compare this with the disease so that faulty genes can be targeted for intervention with new drugs or a cell therapy.

Funding Amount $AUD 505,798.84

Funding Scheme Project Grants

Notes Standard Project Grant