The mezzanine T cell response: intervening at the coal face [ 2018 - 2020 ]

Research Grant

Researchers: Prof Andrew Lew (Principal investigator) ,  Dr Edwin Hawkins ,  Dr Robyn Sutherland

Brief description In an initial immune response, specialised cells in lymph nodes tell T cells to multiply; the stimulated T cells depart and enter target tissue (e.g. lung in the case of flu). We describe a new response whereby the target tissue itself can tell T cells to multiply further. This response in target tissues reveals a new way of altering immune responses. This is especially important as in many diseases, the primary lymph node response has already occurred, so cannot be therapeutically intervened.

Funding Amount $AUD 776,303.19

Funding Scheme Project Grants

Notes Standard Project Grant