grant

Metabolic stress sensing by AMPK: implications for energy balance and isoform-targetting therapeutics [ 2013 - 2015 ]

Also known as: Therapeutics for metabolic diseases

Funded by National Health and Medical Research Council
Managed by St. Vincent's Institute of Medical Research
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1049197]

Researchers: Dr Jon Oakhill (Principal investigator) ,  Dr John Scott

Brief description Metabolic diseases such as obesity, type 2 diabetes and cardiovascular disease impose enormous medical and economic burdens on Western societies. Our research is focussed on the enzyme AMP-activated protein kinase (AMPK) which acts as the fuel gauge of the cell and is a promising drug target for combating metabolic diseases. Our discoveries provide critical insight on how AMPK is switched on by both energy demand and drugs, and will greatly assist development of AMPK-targetted therapeutics.

Funding Amount $AUD 632,188.35

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
AMP-activated protein kinase | Biochemistry and Cell Biology | Biological Sciences | Cell Metabolism | biochemistry | cardiovascular disease | diabetes | drug discovery | kinases | lipid metabolism | metabolic syndrome | obesity |
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