Mediator kinase as a therapeutic target for Wnt/?-catenin dependent malignancies [ 2017 - 2020 ]

Research Grant

[Cite as]

Researchers: Dr Jason Cain Dr Suresh Mathivanan Prof Bryan Williams

Brief description Colorectal cancer is the third leading cause of cancer mortality in Australia and globally. The Wnt/?-catenin signalling pathway is a well established driver of colon cancer growth in >90% of cases. Using sophisticated genetic screens, we identified CDK8/19 as a colon cancer oncogene and critical regulator of Wnt/?-catenin activity. In this proposal, we will use innovative cancer models in mice and human cancer tissues to investigate newly developed CDK8/19 inhibitors for colon cancer therapy.

Funding Amount $AUD 973,697.60

Funding Scheme Project Grants

Notes Standard Project Grant

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