Research Grant[Cite as http://purl.org/au-research/grants/nhmrc/1129689]
Researchers: Dr Jason Cain , Dr Suresh Mathivanan , Prof Bryan Williams
Brief description Colorectal cancer is the third leading cause of cancer mortality in Australia and globally. The Wnt/?-catenin signalling pathway is a well established driver of colon cancer growth in >90% of cases. Using sophisticated genetic screens, we identified CDK8/19 as a colon cancer oncogene and critical regulator of Wnt/?-catenin activity. In this proposal, we will use innovative cancer models in mice and human cancer tissues to investigate newly developed CDK8/19 inhibitors for colon cancer therapy.
Funding Amount $AUD 973,697.60
Funding Scheme Project Grants
Notes Standard Project Grant
- PURL : http://purl.org/au-research/grants/nhmrc/1129689
- nhmrc : 1129689