grant

Mediator kinase as a therapeutic target for Wnt/β-catenin dependent malignancies [ 2017 - ]

Also known as: 5219172

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/GNT1129689]

Researchers: A/Pr Ron Firestein (Principal investigator) ,  Dr Jason Cain Dr Suresh Mathivanan Prof Bryan Williams

Brief description Colorectal cancer is the third leading cause of cancer mortality in Australia and globally. The Wnt/β-catenin signalling pathway is a well established driver of colon cancer growth in >90% of cases. Using sophisticated genetic screens, we identified CDK8/19 as a colon cancer oncogene and critical regulator of Wnt/β-catenin activity. In this proposal, we will use innovative cancer models in mice and human cancer tissues to investigate newly developed CDK8/19 inhibitors for colon cancer therapy.

Funding Amount $949,907.00

Funding Scheme Project Grants

Notes Standard Project Grant

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