Mediator kinase as a therapeutic target for Wnt/β-catenin dependent malignancies [ 2017 - ]

Research Grant

Researchers: A/Pr Ron Firestein (Principal investigator) ,  Dr Jason Cain ,  Dr Suresh Mathivanan ,  Prof Bryan Williams

Brief description Colorectal cancer is the third leading cause of cancer mortality in Australia and globally. The Wnt/β-catenin signalling pathway is a well established driver of colon cancer growth in >90% of cases. Using sophisticated genetic screens, we identified CDK8/19 as a colon cancer oncogene and critical regulator of Wnt/β-catenin activity. In this proposal, we will use innovative cancer models in mice and human cancer tissues to investigate newly developed CDK8/19 inhibitors for colon cancer therapy.

Funding Amount $949,907.00

Funding Scheme Project Grants

Notes Standard Project Grant