Mechanistic and Functional Drivers of Neochromosome Evolution [ 2016 - ]

Research Grant

Researchers: Prof Anthony Papenfuss (Principal investigator) ,  A/Pr Timothy Mercer ,  Prof David Thomas

Brief description Neochromosomes are Frankenstein chromosomes--massive extra chromosomes that are stitched together from 100s of pieces of normal chromosomes. They are found in 3% of cancers, but are common in some types, such as liposarcoma. We have mapped their structure and found they form through punctuated chromosome shattering and gene amplification. We will investigate the precise molecular mechanisms that cause this and the recurrent transcriptional and epigenetic drivers lead to their formation.

Funding Amount $763,771.00

Funding Scheme Project Grants

Notes Standard Project Grant