A mechanistic approach to therapy development for chronic traumatic encephalopathy using small and large animal models of concussion [ 2014 - 2017 ]

Research Grant

Researchers: Prof Robert Vink (Principal investigator) ,  A/Pr Renee Turner ,  Prof Jeffrey Rosenfeld ,  Prof Peter Blumbergs

Brief description Repeated concussion in athletes has recently been associated with the development of a neurodegenerative disorder known as chronic traumatic encephalopathy (CTE). While the neuropathology seems to be well characterised, the mechanisms associated with CTE development are not. This proposal will demonstrate that mechanically induced release of the neurotransmitter substance P accounts for much of the neuropathology in CTE, and will develop a novel therapy that will prevent such development.

Funding Amount $AUD 492,844.86

Funding Scheme Project Grants

Notes Standard Project Grant