grant

Mechanisms underlying generation of Febrile Seizures in mouse models of human familial epilepsy [ 2008 - 2011 ]

Also known as: Changes in brain function that cause Febrile Seizures

Funded by National Health and Medical Research Council
Managed by The University of Melbourne
Managed by University of Melbourne
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/509224]

Researchers: Dr Elisa Hill (Principal investigator)

Brief description Febrile Seizures (FS) affect 3% of children aged 0.5 - 6 yrs and have been proposed as an indicator of severe forms of adult generalized epilepsy. Mechanisms underlying FS generation are unknown although studies of Australian families suffering from epilepsy have linked 2 genes to FS. We have generated mice expressing these 2 genes. Aims and Outcomes: to investigate events triggering FS which will provide important insights into why FS occurs in children. (NB: CIA 2 yr career interruption)

Funding Amount $AUD 304,559.40

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant

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Subjects
Biomedical and Clinical Sciences | Febrile Seizures | GABA A receptors | Medical Infection Agents (Incl. Prions) | Medical Microbiology | brain | epilepsy | genetic disease | ion channels | nerve excitability | sodium channel | transgenic mice |
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