grant

Mechanisms underlying the effects of TNFalpha in bone and haemopoiesis [ 2008 - 2010 ]

Also known as: Understanding how TNFalpha affects bone and blood cell production

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/502612]

Researchers: A/Pr Louise Purton (Principal investigator)

Brief description Recent studies have identified that bone plays an important role in blood cell production. We have discovered that elevated levels of TNF alpha (which increases with ageing and can negatively impact on health) contributes to a blood cell disorder that can progress to leukaemia. There are also reduced numbers of blood stem cells and bone in this mouse model. In these studies we will determine how TNFalpha contributes to blood and bone defects, which may lead to better treatment of such diseases.

Funding Amount $AUD 589,425.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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