Mechanisms underlying the contribution of uremic toxins to cardiorenal syndrome [ 2015 - 2017 ]

Research Grant

Researchers: A/Pr Bing Wang (Principal investigator) ,  Prof Henry Krum (Principal investigator) ,  Dr Andrew Kompa ,  Prof Darren Kelly

Brief description Cardiorenal syndrome (CRS) is an umbrella term that defines disorders of the heart and kidneys whereby “acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other”. We have demonstrated a significant association between heart and kidney fibrosis (scarring) and levels of a uremic toxin called indoxyl sulphate (IS), in relevant animal models and that blockade of production of this toxin reduces cardiac fibrosis. This project aims to explore this association.

Funding Amount $AUD 413,533.44

Funding Scheme Project Grants

Notes Standard Project Grant