The mechanisms responsible for tolerance at the mu-opioid receptor [ 2011 - 2014 ]

Also known as: Development of opioid analgesics that reduce or reverse morphine tolerance

Research Grant

[Cite as]

Researchers: Prof Macdonald Christie (Principal investigator) ,  Dr Billy Chieng Prof Mark Connor

Brief description Strong pain relieving opioid drugs like morphine lose their effectiveness when used for long periods because the single protein target for them in the body loses its� normal signalling functions. This research will determine the mechanisms responsible for this loss of function in brain nerve cells using novel methods to identify the molecular adaptations involved. This will provide a rational framework for development of pain relieving opioid drugs that can maintain long term efficacy.

Funding Amount $AUD 562,815.75

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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