Mechanisms responsible for neurogenic hypertension: Role of a novel interaction between amygdala-hypothalamic GABA pathways and the microRNA regulation of renin [ 2014 - 2016 ]

Also known as: Understanding how hyperactivity of regions of the brain that process the response to stress leads to high blood pressure.

Research Grant

[Cite as]

Researchers: Prof Geoffrey Head (Principal investigator) ,  Dr Francine Marques Dr Pamela Davern Prof Fadi Charchar

Brief description We identified that mice bred to have high blood pressure (hypertension) have an overactive nervous system due to a faulty molecule in a small region of the brain that controls emotion and the response to stress. The high nervous activity affects a hormone in the kidney that may lead to hypertension. The proposal will determine the mechanisms and neurochemicals in the brain that are responsible for magnifying the responses to stress leading to hypertension and test a new therapy to treat high blood pressure.

Funding Amount $AUD 576,538.86

Funding Scheme Project Grants

Notes Standard Project Grant

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