Mechanisms of Regulation of Ribosome Biogenesis and Function in Health and Disease [ 2014 - ]

Research Grant

Researchers: Prof Richard Pearson (Principal investigator)

Brief description The PI3K/AKT signalling pathway drives many cancers and until recently was thought to do so by preventing cancer cell death. We have shown this pathway also regulates the synthesis of ribosomes, the cellular “factories” that make protein and by interfering with PI3K/AKT regulated ribosome synthesis, can kill cancer cells. We aim to establish the mechanisms underlying this regulation of ribosome synthesis and to test the hypothesis that ribosome biogenesis is a novel target for cancer treatment.

Funding Amount $601,420.00

Funding Scheme Research Fellowships

Notes Research Fellowship