Mechanisms regulating excitation-contraction coupling in skeletal muscle [ 2004 - 2008 ]

Research Grant

Researchers: Prof Graham Lamb (Principal investigator) ,  Prof D. George Stephenson

Brief description Muscle contraction occurs when an electrical impulse from a nerve travels over the surface of a skeletal muscle fibre and triggers the release of calcium ions from special stores inside the fibre. However, little is known about the regulatory mechanisms involved in turning on and turning off the calcium release. This project investigates the properties of the calcium release and what processes are involved in regulating it. Information about this is vital for understanding how normal muscle works and why muscles show reduced performance with exercise (muscle fatigue), with aging, and in certain diseases.

Funding Amount $AUD 687,750.00

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant