Mechanisms of premature cranial fusion: role of retinol binding protein 4 in osteogenesis and suture fusion [ 2008 - 2010 ]

Research Grant

Researchers: A/Pr Barry Powell (Principal investigator) ,  Prof Andrew Zannettino ,  Prof David David ,  Prof Peter Anderson ,  Prof Stan Gronthos

Brief description Craniosynostosis is a condition where the skull bones fuse prematurely, affecting skull shape, vision and cognition. It occurs in 1 in 2,500 births. The only treatment is surgery, which is life-threatening, costly and may need to be repeated. By studying how fusion happens in this project we may be able to devise therapies to minimize the risks and need for re-operation. Here, we hope to show that modification of a single substance in the skull of mouse models can prevent premature bone fusion.

Funding Amount $AUD 555,855.45

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant