grant

Mechanisms of PKCepsilon-dependent regulation of beta-cell lipid metabolism and insulin secretion [ 2011 - 2013 ]

Also known as: Islet lipids and insulin secretion

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1009189]

Researchers: Prof Trevor Biden (Principal investigator)

Brief description Lipid loading of the insulin-producing beta cells of the pancreas contributes to the onset of Type 2 diabetes, but the mechanisms are poorly understood. We have recently established that inhibiting the enzyme PKCe helps restore insulin secretion. By better defining the cellular role of PKCe we will clarify how insulin secretion is disrupted by fatty acids and cholesterol.

Funding Amount $AUD 555,892.81

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857