The mechanisms through which opiates cause gastrointestinal dysfunction [ 2013 - 2015 ]

Also known as: Opiate-induced constipation: identifying key targets for therapy

Research Grant

[Cite as]

Researchers: Dr Daniel Poole (Principal investigator) ,  Dr Meritxell Canals Prof Nigel Bunnett

Brief description Opiates are the mainstay analgesics for severe pain. However, their use in pain relief can be greatly limited due to gut-related side-effects. These include chronic constipation, which is mediated through actions on neurons in the intestine. In this proposal we will examine the role of key proteins, known as beta arrestins, in the generation of opiate-induced constipation. Knowledge derived from this study will facilitate the development of analgesics with fewer gastrointestinal side-effects.

Funding Amount $AUD 410,594.79

Funding Scheme Project Grants

Notes Standard Project Grant

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