Mechanisms of nanoparticle-mediated inhibition of asthma [ 2011 - 2013 ]

Research Grant

Researchers: Prof Magdalena Plebanski (Principal investigator) ,  Dr Charles Hardy ,  E/Pr Jennifer Rolland ,  Prof James Friend ,  Prof Robyn O'Hehir

Brief description Ultrafine pollution particles may promote asthma, and there is concern that man-made 'nanoparticles' have a similar effect. Surprisingly, we found that inert toxin-free nanoparticles inhibit asthma. We propose nanoparticles do this by leaving a unique �imprint� in the lung. We will explore how this imprint modifies lung inflammatory and immune regulatory cell function, and investigate particles made from advanced biodegradable polymers as potential therapeutics for inflammatory lung diseases such as asthma.

Funding Amount $AUD 637,921.03

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant