Mechanisms of glucocorticoid resistance in acute lymphoblastic leukaemia [ 2009 - 2011 ]

Research Grant

Researchers: Prof Richard Lock (Principal investigator) ,  A/Pr Jeffrey Craig ,  Prof Richard Saffery

Brief description Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.

Funding Amount $AUD 547,970.74

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant