grant

Mechanisms of Epithelial Damage by the Noxious Smoke Constituent Acrolein [ 2009 - 2014 ]

Also known as: Harmful effects of Toxic Smoke-Borne Chemicals on the Lung

Funded by National Health and Medical Research Council
Managed by The University of Western Australia
Managed by University of Western Australia
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/572580]

Researchers: A/Pr Philip Burcham (Principal investigator) ,  A/Pr Peter Henry

Brief description Due to increasing use of reactive chemicals by terrorists (e.g. chlorine gas), their effects on the lung are receiving increasing attention in the global toxicology community. This project focusses on acrolein, the major cytotoxic substance present in smoke produced on combustion of organic matter. We will explore the mechanisms whereby acrolein and high doses of smoke cause the lung to lose its watertight properties, and also test ways of preventing such damage with drugs.

Funding Amount $AUD 668,813.53

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Medical Biochemistry - Lipids | Medical Biochemistry and Metabolomics | acrolein toxicity | epithelial cells | occupational lung injury | protein damage | pulmonary odema | respiratory disease | smoke inhalation injury |
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