Mechanisms by which Endothelial Selectins regulate Normal and Malignant Stem Cell fate [ 2017 - ]

Research Grant

Researchers: A/Pr Ingrid Winkler (Principal investigator) ,  Prof JeanPierre Levesque

Brief description Hematopoietic stem and progenitor cells (HSPC) reside in the bone marrow (BM) and make all the cells of the blood system. We have found a molecule in the BM which when increased during inflammation, awakens normal HSPC. We previously showed this molecule also helps leukaemia and other cancer stem cells resist chemotherapy. We have now identified the mechanism why. These proposed studies open new therapeutic avenues to sensitise cancer stem cells to therapy enabling long-term cure.

Funding Amount $708,742.00

Funding Scheme Project Grants

Notes Standard Project Grant