Mechanisms of DNA damage-induced oocyte apoptosis and infertility: examination of the role of BH3-only proteins. [ 2011 - 2013 ]

Research Grant

Researchers: A/Pr Clare Scott (Principal investigator) ,  A/Pr Jeffrey Kerr ,  Dr Karla Hutt

Brief description Our ability to prevent or postpone menopause following cancer treatment, is of great importance for female fertility, health and quality of life. We will demonstrate that the death gene of the Bcl-2 family of life and death genes, Puma, is responsible for killing female germ cells after damaging treatment. When Puma is absent, sufficient high quality germ cells are able to survive damaging treatment, allowing normal fertility in mice. The quality of these rescued germ cells will be analysed in detail.

Funding Amount $AUD 495,755.01

Funding Scheme Project Grants

Notes Standard Project Grant