Mechanisms of beta-cell compensation [ 2014 - ]

Research Grant

Researchers: A/Pr David Laybutt (Principal investigator)

Brief description Obesity is a strong risk factor for type 2 diabetes. Obese subjects with “robust” pancreatic beta-cells can sustain a compensatory response. Type 2 diabetes arises in subjects with beta-cells that are “susceptible” to dysfunction and death. We will investigate the role of the adaptive unfolded protein response in beta-cell compensation for obesity-associated insulin resistance. Findings will help explain why some individuals but not others develop type 2 diabetes.

Funding Amount $562,562.00

Funding Scheme Project Grants

Notes Standard Project Grant