grant

Mechanisms of autoantibody mediated axonal injury in inflammatory demyelinating neuropathies [ 2008 - 2012 ]

Also known as: Causes of axonal damage in demyelinating disease

Funded by National Health and Medical Research Council
Managed by The University of Sydney
Managed by University of Sydney
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/512537]

Researchers: Prof John Pollard (Principal investigator) ,  Dr Emily Mathey ,  Prof David Burke

Brief description Destruction of nerve fibres (axons) accompanies demyelination and may be responsible for most of the deficit in multiple sclerosis and immune neuropathies. This project will investigate the role of recently described antibodies against a normal component of the axon in axonal damage in both animal models and in patients with immune neuropathies. The project could have a major effect on approaches to management of these diseases.

Funding Amount $AUD 580,197.21

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Medical Microbiology | Medical Mycology | autoantibodies | autoimmune disease | autoimmune diseases | axonal excitability | axonal injury | inflammatory brain disease | inflammatory nerve disease | multiple sclerosis | nerve injury | neuroimmunology |
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