Mechanism of proteotoxic stress induced type I interferon signalling and implications for human disease [ 2018 - ]

Research Grant

Researchers: Dr Sophia Davidson (Principal investigator)

Brief description All cells have a proteasome system to degrade unwanted proteins. Proteasome dysfunction causes a build-up of proteins that triggers, through an unknown mechanism, activation of the immune system leading to inflammation. People with mutations in genes which code for proteasome activity experience a severe disease known as Proteasome-Associated Autoinflammatory Syndrome. We aim to elucidate the link between protein aggregation and immune activation and employ this knowledge in disease treatment.

Funding Amount $322,952.00

Funding Scheme Early Career Fellowships

Notes Peter Doherty Biomedical ECF