Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/1143412]Brief description All cells have a proteasome system to degrade unwanted proteins. Proteasome dysfunction causes a build-up of proteins that triggers, through an unknown mechanism, activation of the immune system leading to inflammation. People with mutations in genes which code for proteasome activity experience a severe disease known as Proteasome-Associated Autoinflammatory Syndrome. We aim to elucidate the link between protein aggregation and immune activation and employ this knowledge in disease treatment.
Funding Amount $AUD 327,193.32
Funding Scheme Early Career Fellowships
Notes Peter Doherty Biomedical ECF
- nhmrc : 1143412
- PURL : https://purl.org/au-research/grants/nhmrc/1143412
