grant

The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs [ 2018 - 2020 ]

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1139865]

Researchers: A/Pr Tri Phan (Principal investigator) ,  Dr Cindy Ma Dr Melanie Wong

Brief description Why do some patients develop autoimmune diseases such as lupus where the immune system makes antibodies that attack its own body? To answer this, we plan to study a disease where a gene responsible for making antibodies is defective. Patients with mutations in the STK4 gene are unable to regulate the selection processes by which only the right cell is chosen to make antibodies. Understanding how STK4 works may help us unlock the mystery of what causes lupus.

Funding Amount $AUD 657,448.20

Funding Scheme Project Grants

Notes Standard Project Grant

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