The mechanism by which apical-basal polarity complexes regulate the Salvador-Warts-Hippo pathway [ 2010 - 2012 ]

Research Grant

Researchers: A/Pr Helena Richardson (Principal investigator) ,  Dr Nicola Grzeschik ,  Prof Kieran Harvey

Brief description Cancer is a multi-hit process involving the activation of critical signaling pathways leading to increased proliferation, survival and increased invasion-metastasis. We have discovered that a neoplastic tumour suppressor gene, lgl, acts though the Salvador-Warts-Hippo (SWH) tumour suppressor pathway to inhibit cell proliferation and cell survival. Here we use the model organism, Drosophila, and mammalian epithelial cells to determine the mechanism by which Lgl activates the SWH pathway.

Funding Amount $AUD 540,099.69

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant