Mechanism of activation of JAK2 by a class 1 cytokine receptor [ 2012 - 2015 ]

Research Grant

Researchers: Prof Michael Waters (Principal investigator) ,  Dr Andrew Brooks ,  Dr Yann Gambin ,  Prof Kirill Alexandrov

Brief description Cytokine receptors regulate key processes such as red/white blood cell formation, stature, adiposity and lactation. They use JAK kinases to signal to regulated genes. Here we will use sophisticated technologies able to observe single molecules and crystallography to uncover the mechanism used by these receptors to signal into the cell using a well characterised, simple cytokine receptor, the growth hormone receptor.

Funding Amount $AUD 562,742.09

Funding Scheme Project Grants

Notes Standard Project Grant