grant

Mechanism of action of dynamin ring stabilizer compounds controlling the actin cytoskeleton [ 2012 - 2014 ]

Also known as: Ring stabilizer compounds stabilise dynamin and actin in kidney podocytes

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1032771]

Researchers: Prof Phillip Robinson (Principal investigator) ,  Prof Adam Mccluskey

Brief description We will test our hypothesis that ring stabilizer (RS) compounds we invented may become future proteinuric kidney disease therapeutics. The global epidemic of kidney disease eludes present treatments. Dysfunction of podocyte cells accounts for 90% of end-stage kidney diseases. Our pilot data shows that our ring stabilizer compounds restore podocyte function in vitro and kidney function in animal models. We aim to understand their mechanism of action.

Funding Amount $AUD 659,360.77

Funding Scheme Project Grants

Notes Standard Project Grant

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Identifiers
Viewed: [[ro.stat.viewed]]
ACN 633 798 857