Mast cells - bystanders or instigators of airway remodelling in asthma? [ 2010 - 2013 ]

Research Grant

Researchers: Dr J. Margaret Hughes (Principal investigator) ,  A/Pr Janette Burgess ,  Prof Carol Armour ,  Prof Christopher Brightling

Brief description Current asthma treatments have little effect on changes to the breathing tubes in our lungs. The tubes are thickened and stiffer, with more muscle, blood vessels, matrix and mucus. We propose that a particular inflammatory cell, called a mast cell, causes these changes to the breathing tubes and we will find out how it does that. Thus this project will establish why and how the changes to the breathing tubes happen in asthma and reveal how best to target and reverse-prevent them in the future.

Funding Amount $AUD 623,764.19

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant