grant

Manipulating store-operated Ca2+ entry to improve muscle function in dystrophy [ 2012 - 2016 ]

Also known as: Calcium regulation in healthy and dystrophic skeletal muscle

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1025355]

Researchers: Dr Bradley Launikonis (Principal investigator) ,  A/Pr Robyn Murphy ,  Prof Walter Thomas

Brief description Muscle function is regulated in a complex manner by calcium and is impaired in Duchenne muscular dystrophy (DMD). Changes in calcium regulation will be investigated in DMD patients and in an animal model using a novel approach. We will use a combination of novel experimental approaches to manipulate muscles in dystrophic mice and test for improvement in function. Results will determine the viability of a potential treatment.

Funding Amount $AUD 516,163.90

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Cell Physiology | Medical and Health Sciences | Medical Physiology | calcium imaging | dystrophy | excitation-contraction coupling | muscle disease | muscle function | muscular dystrophy | peripheral nervous system (PNS) | skeletal muscle |
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