Full descriptionThe CNS HAND study was primarily conducted among 254 people living with HIV (PLHIV) and 72 HIV-negative persons from a primary care clinic in Sydney, Australia named Holdsworth House General Practice to assess the burden of HIV-associated neurocognitive disorder (HAND) among PLHIV and to validate the CogState computerized cognitive screening tool for the diagnosis of HAND. This baseline study took place between October 2011 and October 2012. Exclusion criteria at the entry of the study was alcohol or substance intoxication. Providing that majority of the study participants continue receiving care at the clinic, their long-term health outcome data on age-related non-AIDS conditions (major neurological and cognitive disorders, cardiovascular diseases, diabetes, osteoporosis, non-AIDS cancers, and chronic kidney, liver and lung diseases) were collected in June 2021 censoring the study end point at the end of April 2021. Three HIV-negative participants were excluded from this long-term outcome study because of seroconversion during the study follow-up period. This deidentified individual participant dataset was used for survival analyses to identify if PLHIV despite under suppressive combination antiretroviral therapy has higher risks for age-related non-AIDS conditions compared to age and lifestyle-matched HIV-negative persons.
Data time period: 2010-10 to 2021-04
Aging | Biomedical and Clinical Sciences | CVD | Cancer | Clinical Sciences | Congitive disorder | Diabetes | Epidemiology | Health Sciences | HIV | Infectious Diseases | Osteoporosis | Survival analysis |
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