Long acting Insulin: Drug design, in vitro activity through to animal model efficacy [ 2008 - 2011 ]

Research Grant

Researchers: A/Pr Lisandra Martin (Principal investigator) ,  A/Pr Sofianos Andrikopoulos ,  Prof Andrea Robinson ,  Prof John Wade

Brief description This research will develop novel insulins that possess improved stability and activity for diabetic patients. The improved pharmacological actions of the modified insulins offer increased treatment options for patients eg. enabling less frequent or invasive medication. Our cross-disciplinary team will (i) design and synthesise insulin derivatives, (ii) explore the activity of the modified insulins by biophysical activity profiles in vitro, (iii) evaluate the in vivo stability and clinical effects.

Funding Amount $AUD 445,011.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant